Grapefruit interaction with certain drugs can kill you

Grapefruit eaten while taking certain drugs can kill you. It may not be the first time you have heard this, but for those who are finding they are taking more prescription drugs in their later years, revisiting the topic can't hurt. I was prompted to write this post after reading an article on the CBC website this morning. If you would like to have a look at the article yourself, please click here.

An article about it on Wikipedia says:  A number of organic compounds, identified as furanocoumarin derivatives, interfere with the hepatic and intestinal enzyme cytochrome P450 isoform CYP3A4 and are therefore primarily responsible for the interaction. However, bioactive compounds in grapefruit juice may also interfere with P-glycoprotein and organic anion transporting polypeptides (OATPs) either increasing or decreasing bioavailability of a number of drugs.

Below, is the video I'm sharing from the CBC website article I read this morning.

For those of you who want to read a more in-depth study about this, click here to read this article from the US National Library of Medicine National Institutes of Health.




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